Frequently asked questions

Dual seropositive

What does it mean to be dual seropositive?

Dual seropositive means that your blood tested positive for anti-CCP and rheumatoid factor (RF). Learn more about what it means to be dual seropositive.

Anti-CCP, anti-cyclic citrullinated peptide.

How do I find out if I’m dual seropositive?

You can find out if you’re dual seropositive by talking to your doctor. Bring these questions to your next appointment.

What if I’m not dual seropositive?

ORENCIA may still be the right treatment for you. See results in other groups of people.


Will my insurance cover ORENCIA?

Many insurance plans cover ORENCIA. To find out if your insurance covers ORENCIA,
call 1-800-ORENCIA (1-800-673-6242) and speak to an insurance specialist who can help verify your coverage.

What if my insurance does not
cover ORENCIA?

For people with insurance that does not cover ORENCIA, there are other ways to save on treatment. Call 1-800-ORENCIA
(1-800-673-6242) to see if you're eligible
for reimbursement.

What should I do if my pharmacy does not accept my ORENCIA co-pay card?

If your pharmacy does not accept the ORENCIA co-pay card, call 1-800-ORENCIA
(1-800-673-6242). Our associates will give you information about another way to take advantage of the benefits using a rebate form. This way, you can continue to take ORENCIA as prescribed by your doctor and
get reimbursed.

If I’m taking ORENCIA as an intravenous infusion, where can I find financial support?

The first step to unlocking co-pay support is to ask your doctor to start the process.


What is ORENCIA?

ORENCIA is a prescription medicine used to treat several different conditions. Explore how ORENCIA helped people who have moderate to severe rheumatoid arthritis, active psoriatic arthritis, or polyarticular juvenile idiopathic arthritis.

How long does it take for ORENCIA to work?

It’s important to know that it may take a little while for you to respond to your new treatment. Many people started feeling better in about 3 to 6 months. Individual results may vary. See more results.


How much ORENCIA do I need to take, and how often do I need to take it?

If you are prescribed ORENCIA self-injection, you should follow your doctor's instructions. The recommended dosage for this under-the-skin injection is 125 mg once weekly. Learn more about how to take ORENCIA and talk to your doctor for more information.

I missed a dose, what should I do?

If you miss a scheduled dose of ORENCIA, talk to your doctor to find out when you should take your next dose. Try your best to take ORENCIA as scheduled, and set reminders on days that you are scheduled to take ORENCIA.

How do I inject ORENCIA?

Your doctor should show you how to properly inject ORENCIA before you try it yourself. Learn more about how to take ORENCIA.

Where do I inject ORENCIA?

If you are self-injecting, it is recommended that you use the front of your thigh or your abdomen, except for the 2-inch area around your navel.

If the injection is being given by a caregiver, the outer area of the upper arms may also be used. Do not attempt to use the upper arm area by yourself, and be sure to choose a different injection site for each new injection. Learn more about how to take ORENCIA.

Can I inject ORENCIA without letting it
warm up?

No. After removing ORENCIA from the refrigerator, let it warm up for 30 minutes to allow it to reach room temperature. Do not attempt to speed up the warming process in any way.

I feel a little bit of burning or pain during injection. Is this normal?

When giving yourself an injection, you may feel a prick from the needle. Sometimes, the medicine can cause slight irritation near the injection site. The discomfort should be mild to moderate. If you have any side effects, including pain, swelling, or discoloration near the injection site, contact your healthcare provider.

How should I store my ORENCIA prefilled syringe or autoinjector?

Store ORENCIA in the refrigerator at 36 °F to 46 °F (2 °C to 8 °C) until you are ready to use. Be sure to keep ORENCIA in the original package and out of the light. DO NOT freeze ORENCIA. Safely throw away medicine that is out of date or no longer needed.

How long can ORENCIA stay out of the fridge? What if my prefilled syringe or autoinjector does not stay cool for an extended period of time? Is it dangerous
to use?

Contact 1-800-ORENCIA (1-800-673-6242) for details.

How should I keep my prefilled syringes or autoinjector cool while traveling?

If you need to take your prefilled syringes or autoinjector with you, store them in a cool carrier between 36 °F and 46 °F (2 °C and
8 °C) until you are ready to use. DO NOT freeze ORENCIA. Keep ORENCIA in the original carton and protected from light. Your healthcare provider may know about special carrying cases for injectable medicines.

Can I take my prefilled syringes or autoinjector on an airplane?

Generally, you are allowed to carry ORENCIA prefilled syringes or autoinjector with you on an airplane. Be sure to carry the prefilled syringes or autoinjector with you on board the plane, and do not put them in your "checked" luggage. You should carry ORENCIA prefilled syringes or autoinjector with you in your travel cooler at a temperature of 36 °F to 46 °F (2 °C to 8 °C) until you are ready to use. Keep ORENCIA in the original carton, with its original preprinted labels, and protected from light.

What should I do with my syringe or autoinjector after injecting ORENCIA?

It is important to properly dispose of syringes in a Sharps container. ORENCIA On CallTM offers a Sharps disposal service. Find out more by calling
(1-800-673-6242). Do not throw away used syringes in the household trash and do not recycle them. If you don't have an FDA-cleared Sharps disposal container, you may dispose of your used syringe in a hard plastic container with a screw-on cap (such as an empty detergent bottle) or in a metal container with a plastic lid (such as a coffee can). When the container is full, place adhesive tape around the cap or lid to make sure the cap or lid does not come off. Ask your doctor, nurse, or pharmacist about state and local laws regarding the proper disposal of medical products that contain needles.

What should I do when my Sharps container is full?

If you are signed up for ORENCIA On CallTM, you can mail back your filled Sharps container using the prepaid postage package. As soon as we receive it, we'll send you a new container. Find out more by calling 1-800-ORENCIA

Rheumatoid arthritis (RA)

What is moderate to severe rheumatoid arthritis (RA)?

RA is an autoimmune disease that causes inflammation in your joints. This inflammation can cause pain, swelling, stiffness, and reduced mobility. RA is a chronic illness, which means it doesn't go away. Over time, it may lead to permanent joint damage and physical disability. Appropriate diagnosis and treatment are important to best manage your RA. Learn more about how ORENCIA helps stop RA.

What causes RA?

RA is an autoimmune disease, meaning your immune system becomes overactive and mistakenly attacks the healthy tissues in your own body. In RA, a key target of the overactive immune system is the lining of the joints, also known as the synovium.

The exact cause of RA is unknown. RA may be influenced by many risk factors, including genes, infection, hormonal changes, or environmental factors. Find out more about RA.

What are the symptoms of RA?

RA affects the joints in your body, so it can have many symptoms, including joint pain and reduced mobility. Learn more about RA.