For questions about BMS medicines during this time,
please call 1-800-721-8909.

Blood tests and exams
are useful to diagnose RA

hand x-ray and blood vial of a patient

They help your doctor build a bigger picture

When assessing your RA, your doctor looks at different pieces of information:

Blood tests

X-rays and other scans

Background and medical history

Symptoms and
physical exams

This information can be put together like a set of clues—building a bigger picture to help you and your doctor better understand your RA.

Blood tests help reveal differences in your blood

You’ve likely already had blood tests for your RA. They can reveal differences in your blood. In some cases, you might hear these differences called biomarkers.

What is a biomarker?

The term biomarker might sound complicated, but it’s just another way to describe a unique characteristic of your disease that can
be measured.

So, if not everyone with RA is the same, what are the differences? For some people, it’s that they tested positive for certain biomarkers.

Here are some of the biomarkers that can be found in your blood

Anti-CCP is a biomarker that may be found in the blood if the immune system is overactive. It is generally only found in people who have RA. However, not all RA patients have anti-CCP. Around 70% of RA patients are positive for anti-CCP.
Anti-CCP may contribute to inflammation and joint damage seen in RA. Sometimes anti-CCP is called ACPA (anti-citrullinated protein antibody).

Research is still ongoing to understand the role of anti-CCP in RA.

RF is a biomarker that may be found in the blood if the immune system is overactive. It may be found in people who have RA, as well as people who have other diseases (such as lupus, or Sjogren's syndrome). Keep in mind that not all RA patients have RF. Around 75% of RA patients are positive for RF. RF may contribute to inflammation and joint damage seen in RA.

ESR is a biomarker that measures how fast red blood cells sink to the bottom of a test tube. This speed increases when there is inflammation happening in the body. ESR may increase because of inflammation caused by many different things—like an injury, an infection, or a disease like RA. Keep in mind that an ESR test cannot tell you exactly why or where you have inflammation.

CRP is a biomarker that may be found in the blood when there is inflammation happening in the body. CRP may be found because of inflammation caused by many different things—like an injury, an infection, or a disease like RA. Keep in mind that a CRP test cannot tell you exactly why or where you have inflammation.

If you tested positive for anti-CCP and RF, then you’re dual seropositive. If you are, ORENCIA may be right for you.

Anti-CCP, anti-cyclic citrullinated peptide; CRP,
C-reactive protein; ESR, erythrocyte sedimentation rate.

Ask your doctor what your blood test results showed