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  • 1-800-ORENCIA

The site is intended for US residents 18 years of age or older.

 

Adult Rheumatoid Arthritis (RA): ORENCIA® (abatacept) is a prescription medicine that reduces signs and symptoms in adults with moderate to severe RA, including those who have not been helped enough by other medicines for RA. ORENCIA may prevent further damage to your bones and joints and may help your ability to perform daily activities. In adults, ORENCIA may be used alone or with other RA treatments other than Janus kinase (JAK) inhibitors or biologic disease-modifying antirheumatic drugs (bDMARDs), such as tumor necrosis factor (TNF) antagonists.

The concomitant use of ORENCIA with other potent immunosuppressants [e.g., bDMARDs, JAK inhibitors] is not recommended.

Polyarticular Juvenile Idiopathic Arthritis (pJIA): ORENCIA® (abatacept) reduces signs and symptoms in patients 2 years of age and older with moderate to severe polyarticular JIA. ORENCIA may be used alone or with methotrexate (MTX).

The concomitant use of ORENCIA with other potent immunosuppressants [e.g., bDMARDs, JAK inhibitors] is not recommended.

Adult Psoriatic Arthritis (PsA): ORENCIA® (abatacept) is a prescription medicine that reduces signs and symptoms in adults with active psoriatic arthritis (PsA). In adults, ORENCIA may be used alone or with other PsA treatments.

The concomitant use of ORENCIA with other potent immunosuppressants [e.g., bDMARDs, JAK inhibitors] is not recommended.

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What Is Moderate to Severe Polyarticular Juvenile Idiopathic Arthritis (pJIA)?

Polyarticular Juvenile Idiopathic Arthritis (pJIA), also known as Juvenile Rheumatoid Arthritis, is an autoimmune disease that affects children and adolescents. Like adult Rheumatoid Arthritis (RA), pJIA causes chronic pain, stiffness, and swelling of the joints.

pJIA is a disease of the immune system. The immune system works to protect the body against attacks from threats like bacteria or viruses. But when it’s not working correctly—such as with pJIA—the immune system can mistakenly attack your child’s body.

You will likely have many decisions to make regarding treatment paths. You can learn more about ORENCIA here, so that you and your child’s doctor can decide if ORENCIA is the right path to take.

What are some of the most common symptoms of pJIA?

Like adult RA, pJIA causes symptoms that impact your child’s life:

  • Chronic pain
  • Stiffness
  • Swelling of the joints

How may ORENCIA help my child?

ORENCIA is a pJIA treatment for moderate to severe pJIA that may
help your child with everyday activities, such as:

  • Dressing themselves (put on a sweater over head)
  • General hygiene (bathing, brushing teeth, combing hair)
  • Reaching for things (large game box, book)
  • Gripping objects (write with a pen, turn a faucet, open a door)
  • Doing activities (ride a bike, chores, run and play)

Work with your child's rheumatologist to determine if
ORENCIA is right for your child.

Your child's results may vary.

ORENCIA® (abatacept) reduces signs and symptoms in children 2 years of age and older and adolescents with moderate to severe pJIA

ORENCIA monthly intravenous (IV) infusion

for 6 years of age and older

Impact
on flares

ORENCIA weekly
injection with prefilled syringe

for 2 years of age and older

ORENCIA IV clinical trial results for pJIA

ORENCIA IV infusion was studied in 190 children and adolescents aged 6 to 17 who had moderate to severe pJIA. The patients studied had subtypes of pJIA that at disease onset included polyarticular (involving 5 or more joints) (64%), oligoarticular (involving a few joints) (16%), and systemic without systemic manifestions (involving 1 or more joints) (20%).

The study included patients who were new to biologics (70%) and patients who previously had an inadequate response to biologics, such as Enbrel® (etanercept) or Humira® (adalimumab).

ORENCIA was shown to:

Your child’s results may vary.

What were the side effects of ORENCIA in this trial?

  • The most common infections were upper respiratory tract infection and nasopharyngitis*
  • Other events that occurred in at least 5% of patients were headache, nausea, diarrhea, cough, fever, and abdominal pain
  • A total of 6 serious adverse events (acute lymphocytic leukemia, ovarian cyst, varicella infection, disease flare [2 cases], and joint wear) were reported during the initial 4 months of treatment with ORENCIA

*Nasopharyngitis: Inflammation of the nose and throat (characterized by sneezing, stuffy nose, cough, sore throat).

 

ORENCIA may reduce your child’s risk of flares

In the ORENCIA IV clinical study, patients who reduced their signs and symptoms with ORENCIA after 4 months were split into 2 groups.

  • Group 1: 60 patients continued taking ORENCIA IV
  • Group 2: 62 patients received placebo

For the next 6 months, doctors monitored both groups for worsening signs and symptoms of pJIA. In other words, they checked for flares.

Patients who continued taking ORENCIA were only about a third as likely to experience a flare as those who had received placebo.

Your child’s results may vary.

 

 

ORENCIA self-injection reduced symptoms
of pJIA

ORENCIA self-injection was given to 205 patients aged 2 to 17 with moderate to severe pJIA.

Treatment was given once weekly for 4 months, and dosing was based on body weight. Improvements in signs and symptoms were similar for ORENCIA self-injection and ORENCIA IV.

Your child's results may vary.

What were the side effects of ORENCIA in this trial?

Side effects for ORENCIA self-injection in the trial were consistent with the ORENCIA IV trial.

There were no reported cases of hypersensitivity reactions. Local injection-site reactions occurred at a frequency of 4.4%.

Selected Important Facts About ORENCIA

Most common side effects

The most common side effects of ORENCIA include:

  • Headache
  • Upper respiratory tract infection
  • Sore throat
  • Nausea

In children and adolescents, other side effects may include:

  • Diarrhea
  • Cough
  • Fever
  • Abdominal pain

Please read the Important Facts About ORENCIA below, including other serious side effects.

ORENCIA offers 2 ways to treat

Your doctor will discuss which option is best for your child.

Monthly IV infusions

An ORENCIA IV (through a vein) infusion is given once a month at the doctor’s office or infusion center and usually takes about 30 minutes. The infusion (only for children and adolescents 6 years of age and older) is given in your child’s arm. When the needle is placed, he or she may feel a pinch similar to a shot.

Weekly self-injection

ORENCIA self-injection is a subcutaneous (under the skin) shot with a prefilled syringe (only for children and adolescents 2 years of age and older). After initial training at your doctor’s office, you or your child can do this once-weekly injection yourself in the comfort of your own home.

Injection video for pJIA caregivers

If your child has pJIA and you’re responsible for administering their ORENCIA with a prefilled syringe, check out this helpful injection video. It’s a kid-friendly video, so you and your child can learn more about dosing ORENCIA by watching it together!

But remember, you and your child must be trained by a healthcare professional on how to properly inject ORENCIA before doing it at home.

Resources

Thumbnail for the ORENCIA® JIA Patient brochure Thumbnail for the ORENCIA® JIA Patient brochure

pJIA Patient Brochure

Learn all about ORENCIA, including information on clinical trials, dosing, and financial assistance.

Thumbnail for the ORENCIA® JIA Registry brochure Thumbnail for the ORENCIA® JIA Registry brochure

pJIA Registry Brochure

Your child’s participation in the registry can help the pJIA community better understand the long-term safety and effectiveness of ORENCIA.

Important Facts About ORENCIA® (abatacept)

This is a summary of important information that you need to know in order to take ORENCIA safely. Work with the rheumatologist to make the treatment suitable and safe for you or your loved one. Keep this information, so you can refer to it before and during your treatment.

  • Look out for the following icons as you read:

  • Talk to your rheumatologist

  • Call a healthcare provider right away

  • Helpful information to remember

 

What is ORENCIA?

ORENCIA (abatacept) is a prescription biologic medicine for:

Adult Rheumatoid Arthritis (RA)

ORENCIA is used to reduce signs and symptoms of moderate to severe Rheumatoid Arthritis in adults 18 years and older. Taking ORENCIA may prevent further damage to your bones and joints, and may help your ability to perform daily activities. ORENCIA may help those who are not getting the results they need with other medicines for RA.

In adults, ORENCIA may be used alone or with other RA treatments other than Janus kinase (JAK) inhibitors or biologic disease-modifying antirheumatic drugs (bDMARDs), such as tumor necrosis factor (TNF) antagonists.

Polyarticular Juvenile Idiopathic Arthritis (pJIA):

ORENCIA is used to reduce signs and symptoms of moderate to severe polyarticular JIA in patients 2 years of age and older. ORENCIA may be used alone or with methotrexate (MTX).

Adult Psoriatic Arthritis (PsA)

ORENCIA is used to reduce signs and symptoms of active Psoriatic Arthritis in adults 18 years and older. In adults, ORENCIA may be used alone or with other PsA treatments.

ORENCIA should not be used with other strong medicines that affect the immune system, such as bDMARDs and JAK inhibitors.

  • ORENCIA is for adults 18 years and older with moderate to severe RA.
  • ORENCIA is for patients 2 years of age and older with moderate to severe pJIA.
  • ORENCIA is for adults 18 years and older with active PsA.
  • ORENCIA should not be used with bDMARDs and JAK inhibitors.
  • ORENCIA has not been studied in children under 2 years of age.
  • ORENCIA has not been studied in children for uses other than pJIA.

ORENCIA is available in two forms:

ORENCIA intravenous (IV) infusion is given by your healthcare provider through a vein in your arm.

  • ORENCIA IV is approved for patients 6 years and older.
  • ORENCIA IV has not been studied in children under the age of 6.
OR

ORENCIA subcutaneous (SC) injection is a shot that is given just under your skin. It is available as a prefilled syringe or a ClickJect™ Autoinjector.

  • ORENCIA SC prefilled syringe is available for patients 2 years and older.
  • PJIA patients may self-inject with ORENCIA or the patient’s caregiver may administer ORENCIA if both the healthcare practitioner and the parent/legal guardian determines it is appropriate.
  • The ability of pediatric patients to self-inject with the autoinjector has not been tested.
  • Talk to your rheumatologist about the best way for you or your child to receive ORENCIA.
 

What should I discuss with my rheumatologist before starting ORENCIA?

  • Talk to your rheumatologist about all of your medical conditions, including if:
    • You have any kind of infection, as you may have a higher chance of getting serious side effects from an infection while taking ORENCIA. Infections include:
      • Small infections (such as an open cut or sore) to whole body infections (such as the flu).
      • Any infection that will not go away or a history of infections that keep coming back.
      • Viral hepatitis, a viral infection that affects the liver. Tell your rheumatologist if you have or have ever had viral hepatitis. Before starting ORENCIA, your rheumatologist may examine you for hepatitis.
      • Tuberculosis (TB), a type of lung infection. Tell your rheumatologist if you have ever had TB or a positive skin test for TB, or have recently been in close contact with someone who has ever had TB. Before starting ORENCIA, your rheumatologist may check you for TB or do a skin test. Call your rheumatologist if you notice any symptoms of TB, including: a cough that does not go away, weight loss, fever, or night sweats.
    • You have allergies to the ingredients of ORENCIA. For a list of ingredients, see What are the ingredients in ORENCIA? in the Patient Information section of the Full Prescribing Information.
    • You have Chronic Obstructive Pulmonary Disease (COPD), a type of lung disease.
    • You have diabetes. Your healthcare provider may tell you to use a different way to monitor your blood sugar levels on the day that you receive ORENCIA IV infusion. ORENCIA IV contains maltose, which can alter the blood sugar readings with certain types of blood glucose monitors.
    • You have a family or personal history of skin cancer, or see any growths or changes in the appearance of your skin during or after treatment with ORENCIA. Some people treated with ORENCIA have developed skin cancer.
  • Tell your rheumatologist about all of your medical treatments, including if:
    • You are scheduled to have surgery.
    • You recently received or are scheduled to receive vaccinations. If you are receiving ORENCIA, and for 3 months after you stop receiving ORENCIA, you should not take live vaccines.
    • You are taking:
      • Other medications for RA, pJIA, or PsA.
      • Prescription medications or over-the-counter medications.
      • Vitamins or herbal supplements.
  • Let your rheumatologist know if you are a woman who is:
    • Pregnant or considering pregnancy. It is not known if ORENCIA can harm an unborn baby. If ORENCIA is taken during pregnancy, talk to your healthcare provider before your baby receives any vaccines.
    • There is a registry for pregnant women exposed to ORENCIA. The purpose of this registry is to check the health of the pregnant mother and her child. Women are encouraged to call the registry themselves or ask their healthcare provider to contact the registry for them by calling 1-877-311-8972.
    • Breastfeeding or planning to breastfeed. It is not known if ORENCIA passes into breast milk. Talk to your healthcare provider about the best way to feed your baby if you use ORENCIA.

What should I avoid while I am on ORENCIA?

ORENCIA and other medicines may affect each other, which could cause serious side effects. You should avoid taking ORENCIA with other biologics that may affect your immune system. Doing so may increase your chances of getting a serious infection.

  • Tell your rheumatologist if you are taking other biologic medicines, such as:
  • Enbrel® (etanercept)
  • Humira® (adalimumab)
  • Remicade® (infliximab)
  • Kineret® (anakinra)
  • Rituxan® (rituximab)
  • Simponi® (golimumab)
  • Cimzia® (certolizumab pegol)
  • Actemra® (tocilizumab)
  • Talk to your rheumatologist and your other healthcare providers before you begin to take anything new or if you have any changes to your medications during your treatment with ORENCIA. It is a good idea to keep an up-to-date list of all of your medicines, vitamins, and herbal supplements on hand to show your doctors and pharmacists.
 

What are the possible side effects of ORENCIA?

This is a list of some of the possible side effects of ORENCIA for your reference.

  • Talk to your rheumatologist about any side effect that may be bothering you. Your rheumatologist can work with you to manage side effects throughout your treatment.
Serious side effects

Serious side effects are those that may require medical treatment or hospitalization, cause permanent damage, or be life-threatening or sometimes even fatal. Talk to your healthcare provider about any concerns you may have.

  • Infections. ORENCIA can make you more likely to get infections or make the infections that you have worse. In some cases, these infections have been fatal. Symptoms of an infection include:
    • Fever
    • Cough
    • Warm, red, or painful skin
    • Feeling very tired
    • Flu-like symptoms
  • Call your healthcare provider right away if you feel sick or have any of the symptoms of an infection.
  • Allergic reactions. Allergic reactions can happen with ORENCIA. Symptoms of an allergic reaction may include:
    • Hives
    • Swollen face, eyelids, lips, or tongue
    • Trouble breathing
  • Seek urgent medical attention if you have any of the symptoms of an allergic reaction.
  • If you have the hepatitis B virus, talk to your healthcare provider as hepatitis B can become an active infection while you use ORENCIA. Your rheumatologist may do blood tests before treatment with ORENCIA to check if you have hepatitis B.
  • If you are receiving or are scheduled to receive vaccinations, it is important to know that:
    • You should not receive live vaccines while taking ORENCIA.
    • You can receive non-live vaccines, such as pneumococcal and inactivated influenza (flu) vaccines.
    • ORENCIA may also cause some other vaccinations to be less effective.
  • Talk to your rheumatologist about your vaccination plans.
  • If you have Chronic Obstructive Pulmonary Disease (COPD), you may experience breathing problems more often while taking ORENCIA. Call your healthcare provider if you experience any of the following:
    • Worsened COPD
    • Cough
    • Trouble breathing
  • Certain kinds of cancer (malignancies) have been reported in people using ORENCIA. It is not known if ORENCIA increases your chances of developing certain kinds of cancer.

Most common side effects

The most common side effects of ORENCIA include:

    • Headache
    • Upper respiratory tract infection
    • Sore throat
    • Nausea

In children and adolescents, other side effects may include:

    • Diarrhea
    • Cough
    • Fever
    • Abdominal pain

These are not all of the possible side effects of ORENCIA. If you have any questions or want more information about side effects, ask your rheumatologist or healthcare provider.

If you experience any side effects and would like to report them to the FDA, you can call 1-800-FDA-1088.

 

How will I receive ORENCIA?

ORENCIA is available in two forms, as intravenous (IV) infusions and as subcutaneous (SC) injections. Work with your rheumatologist to determine the right treatment plan for you or your child.

ORENCIA IV infusion is given by a healthcare provider through a vein in your arm.

  • ORENCIA IV is approved for children 6 years and older.
  • ORENCIA IV has not been studied in children under the age of 6. 
    • You will receive your first three infusions 2 weeks apart from each other (Weeks 0, 2, and 4). After that, you will receive an infusion every 4 weeks.
    • Each infusion takes about 30 minutes, though actual time in the clinic will be longer.

ORENCIA SC injection is a shot that is given just under your skin. It is available as a prefilled syringe or ClickJect™ Autoinjector.

  • ORENCIA SC prefilled syringe is available for patients 2 years and older.
  • PJIA patients may self-inject with ORENCIA or the patient’s caregiver may administer ORENCIA if both the healthcare practitioner and the parent/legal guardian determines it is appropriate.
  • The ability of pediatric patients to self-inject with the autoinjector has not been tested.

If your rheumatologist decides that your injections can be given at home, you or your caregiver will receive training on how to prepare and inject ORENCIA. Do not try to inject ORENCIA until you have been shown the right way by your rheumatologist or healthcare provider.

Please click here to read the Patient Information in the Full Prescribing Information.

More Important Facts

Selected Important Facts About ORENCIA® (abatacept)

ORENCIA can cause serious side effects, including serious infections, allergic reactions, hepatitis B infection in carriers of the virus, interactions with vaccines, respiratory problems with COPD, and cancer. Side effects of ORENCIA, which are considered common, include: headache, upper respiratory tract infection, sore throat and nausea. Other side effects in children and adolescents may include diarrhea, cough, fever, and abdominal pain. This is not a complete list of all side effects with ORENCIA. Tell your healthcare provider if you have any side effects while taking ORENCIA.

Please read more information about potential side effects with ORENCIA throughout this website.