RA Treatment | Orencia® (abatacept)

Oh, yes I can!(TM) / Moderate to Severe Rheumatoid Arthritis RA

Could it be time for a change in treatment?

Meet patients who have experienced the difference ORENCIA can make

Barbara and Lucy are two patients on ORENCIA who are living with
moderate to severe RA. Select a video below to hear about their
experience with ORENCIA, and the difference it has made in their daily
lives. While these stories are not representative of every patient, they
suggest how ORENCIA may work for some people.

Meet Lucy, and learn about how ORENCIA has helped her.

Find out what Barbara's done to take control of her RA.

Safety Information About Serious Infections

Patients receiving ORENCIA have a higher chance of getting infections including pneumonia, and other infections caused by viruses, bacteria, or fungi.

Considering ORENCIA?

Learn about THE ORENCIA^® (abatacept) COPAY PROGRAM^™, our program for new and existing ORENCIA patients with commercial insurance that pays for ORENCIA.

•	Eligible patients pay the out-of-pocket cost up front for each infusion.
•	The program will credit you the full out-of-pocket drug cost minus $50 for each infusion up to $5,000 per 12 month period.
•	Enrollment is for 12 months. Patients can re-enroll upon the completion of every 12 month period.
•	Offer covers cost of the medication copay only. This offer is valid in the United States, excluding Massachusetts or where it is prohibited by law. Other restrictions and exclusions may apply. Limited time offer.

Keep an open mind and talk to your rheumatologist

Rheumatoid arthritis is usually a chronic, progressive disease. This means even if you're on treatment, whether or not you're still having symptoms, your RA could be continuing to damage your joints more and more over time.

By finding the right treatment plan for you, you may be able to slow down the progression of joint damage and as well as reduce pain and fatigue.

ORENCIA is a prescription medicine used to treat:

•	Adults with moderate to severe RA who have not been helped enough by their treatment
•	Children over the age of 6 with moderately to severely active polyarticular JIA

ORENCIA has been shown to:

•	Relieve the pain, swelling, and fatigue of RA
•	Reduce the signs and symptoms of JIA
•	Control the advance of joint damage
•	Help improve physical and emotional health-related quality of life

Next section: How ORENCIA is different

ORENCIA® (abatacept) Important Safety Information

Indication and Usage
ORENCIA® (abatacept) is a prescription medicine that reduces signs and symptoms in adults with moderate to severe rheumatoid arthritis (RA), including those who have not been helped enough by other medicines for RA. ORENCIA may prevent further damage to your bones and joints, and may help your ability to perform daily activities. ORENCIA also reduces signs and symptoms in children and adolescents 6 years of age and older with moderate to severe polyarticular juvenile idiopathic arthritis (JIA).

ORENCIA can also make your immune system less able to fight infections, so you may be more likely to get infections or any infection you have may get worse. It is important to tell your doctor if you think you have any infections.

Important Safety Information About ORENCIA^® (abatacept)

Before you receive treatment with ORENCIA, a lyophilized powder for intravenous infusion, you should tell your doctor about all your medical conditions, including if you:

	have any kind of infection even if it is small (such as an open cut or sore) or an infection that is in your whole body (such as the flu).
	have an infection that will not go away or a history of infections that keep coming back.
	have had tuberculosis (TB), a positive skin test for TB, or if you recently have been in close contact with someone who has had TB. If you get any of the symptoms of TB (a dry cough that doesn't go away, weight loss, fever, night sweats), call your doctor right away. Before you start ORENCIA, your doctor may examine you for TB or perform a skin test.
	have or have had viral hepatitis. Before you use ORENCIA, your doctor may examine you for hepatitis.
	have a history of chronic obstructive pulmonary (lung) disease (COPD).
	are scheduled to have surgery.
	are allergic to any of the following ingredients in ORENCIA: abatacept, maltose, monobasic sodium phosphate, or sodium chloride for administration.
	recently received a vaccination or are scheduled for any vaccination. You should not take live vaccines if you are receiving ORENCIA.
	have diabetes and use a blood glucose monitor to check your sugar levels. The infusion of ORENCIA contains maltose, a sugar that can give falsely high blood glucose readings with some monitors on the day you receive your infusion. Your doctor may tell you to use a different way to monitor your blood sugar levels.
	are pregnant, planning to become pregnant, or are thinking about becoming pregnant. It is not known if ORENCIA can harm your unborn baby.
	are breast-feeding. You will need to decide to either breast-feed or receive treatment with ORENCIA, but not both.
	take any other kinds of medicine, including prescription and nonprescription medicines, vitamins, and herbal supplements.
	are taking other biologic medicines to treat RA or JIA such as: Enbrel^® (etanercept), Humira^® (adalimumab), Remicade^® (infliximab), Kineret^® (anakinra) or Rituxan^® (rituximab). You may have a higher chance of getting a serious infection if you take ORENCIA with other biologic medicines.

Possible Side Effects of ORENCIA® (abatacept)

ORENCIA can cause serious side effects including:

	Serious infections. Patients receiving ORENCIA have a higher chance of getting infections including pneumonia, and other infections caused by viruses, bacteria, or fungi. Call your doctor immediately if you feel sick or get any of the following signs of infection: fever, feel very tired, cough, feel flu-like, or warm, red or painful skin.
	Allergic reactions. Allergic reactions can happen on the day of treatment or the day after receiving ORENCIA. Tell your doctor or get emergency medical help right away if you have hives, swollen face, eyelids, lips, tongue, throat or trouble breathing.
	Cancer (malignancies). Certain kinds of cancer have been reported in patients receiving ORENCIA. It is not known if ORENCIA increases your chance of getting certain kinds of cancer.
	Vaccinations. You should not receive ORENCIA with certain types of vaccines. ORENCIA may cause some vaccinations to be less effective.
	Respiratory problems in patients with COPD. You may get certain respiratory problems more often if you receive ORENCIA and have COPD, including: worsened COPD, pneumonia, cough, or trouble breathing.

The more common side effects with ORENCIA in both adults and children are headache, upper respiratory tract infection, sore throat, and nausea. Other side effects in children may include diarrhea, cough, fever, and abdominal pain.

Please read the Patient Information in the Full Prescribing Information.

ORENCIA is a registered trademark, and "Oh, yes I can!^™ ", The Circle, THE ORENCIA^® (abatacept) COPAY PROGRAM^™, and the Satisfaction RAter are trademarks of
Bristol-Myers Squibb. All other trademarks are the property of their respective owners.

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