Dosing and administration for ORENCIA® (abatacept) SC

ORENCIA SC dosing1

ORENCIA SC (125-mg) should be administered once weekly and may be initiated with or without an ORENCIA IV loading dose.

For patients initiating therapy with an IV loading dose, ORENCIA should be initiated with a single IV infusion (as per body weight categories listed in the ORENCIA IV adult dosing by weight table), followed by the first 125-mg SC injection administered within a day of the IV infusion.

Patients transitioning from ORENCIA IV therapy to SC administration should administer the first SC dose instead of the next IV dose.

Note: ORENCIA SC is available for adults only and is intended for use under the guidance of a physician or healthcare practitioner.

ORENCIA prefilled syringe with Ultrasafe Passive® needle guard1

ORENCIA Prefilled syringe

Preparation and administration1

Supplies needed for ORENCIA SC injection:

  • Prefilled syringe with UltraSafe Passive® Needle Guard
  • Alcohol swab
  • Adhesive bandage
  • Cotton ball or gauze
  • Sharps disposal

General injection instructions1

For more detailed administration information:

Preparing an ORENCIA injection

1. Preparing for an ORENCIA injection Remove 1 single-use ORENCIA prefilled syringe from the refrigerator and let it warm up for 30 to 60 minutes to allow it to reach room temperature.


2. Inspect Look for particulate matter and discoloration prior to administration; do not use if either are present; ORENCIA SC should be clear and colorless to pale yellow.

Prepare injection site

3. Choose and prepare an injection site Rotate injection sites and do not inject into areas where the skin is tender, bruised, red, or hard.


4. Inject ORENCIA Inject the full amount in the syringe.


5. Disposal Discard used syringes into biohazard containers.

Note: ORENCIA SC injection, 125 mg/syringe is not intended for IV infusion. For more detailed administration information, see the Full Prescribing Information.

Storage and handling for ORENCIA SC1

  • ORENCIA solution supplied in a prefilled syringe should be refrigerated at 2°C to 8°C (36°F to 46°F)
  • Do not use beyond the expiration date on the prefilled syringe*
  • Protect from light by storing in the original package until time of use
  • Do not allow the prefilled syringe to freeze
If you find any product defects or the syringe is past its expiration date, call 1-800-ORENCIA for a replacement.

ORENCIA® (abatacept) indicated for moderate to severe RA

Selected Important Safety Information


  1. ORENCIA (abatacept) [package insert]. Princeton, NJ: Bristol-Myers Squibb.

Contact BMS Access and Support
Monday through Friday
8 am to 8 pm EST

For the latest from Bristol-Myers Squibb
Sign-up here »

You are leaving this site.

You are now leaving This site may provide links or references to other Web sites not affiliated with Bristol-Myers Squibb. Bristol-Myers Squibb is not responsible for the content of such other sites and shall not be liable for any damages or injury arising from users' access to such sites. Links to other sites are provided only as a convenience to users of our site.

You are now leaving You are being redirected to another Bristol-Myers Squibb site.

Would you like to leave this site?


Please verify that you are a US Healthcare Professional

This information is intended for US Healthcare Professionals

Hold your phone upright to continue browsing